Panagiotis Mastrodimitris was born in 1934 in Mantoudi, Evia. He gained a doctorate in Greek language and literature in 1970 from Athens University, where he worked as an assistant tutor (1959-61). He spent five years teaching in secondary schools and in 1966 he joined the Modern Greek faculty at Athens University.
He was a scholar at the Greek Institute of Byzantine and Post Byzantine Studies in Venice (1970-71) and went on to teach Modern Greek Language and Literature at Thessaloniki University (1972-75). He was Professor of Modern Greek at Athens University (1981-2001).
A member of professional associations in Greece and abroad, Mastrodimitris has taken part in many Greek and international conferences.
He won the Kostas and Eleni Ouranis Foundation Essay Award (1989) for his Five Essays on Modern Greek Prose, and the State Essay and Literary Criticism Award (1992) for his Perspectives and Approaches.